Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.76 |
| ▸ | CHKA | P35790 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | HBB | P68871 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28588179 | 0.98 | CHRM5 (0.73) | CHRM5CHKAMAPTSMN1; SMN2KMT2A | |
| Bicarbonate SCHEMBL28267252 | 0.98 | CHRM5 (0.73) | CHRM5CHKAMAPTSMN1; SMN2KMT2A | |
| Acetic Acid SCHEMBL7780301 | 0.93 | CHRM5 (0.73) | CHRM5CHKAMAPTSMN1; SMN2KMT2A | |
| Acetone SCHEMBL28700630 | 0.91 | CHRM5 (0.76) | CHRM5CHKAMAPTSMN1; SMN2KMT2A | |
| Bicarbonate SCHEMBL28588177 | 0.89 | CHRM5 (0.67) | CHRM5CHKAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL28166029 | 0.88 | CHRM5 (0.73) | CHRM5CHKAMAPTSMN1; SMN2KMT2A | |
| Benzene SCHEMBL28113160 | 0.87 | CHRM5 (0.89) | CHRM5CHKAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL8664726 | 0.87 | CHRM5 (1.00) | CHRM5CHKAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL189 | 0.87 | — | — | |
| Bicarbonate SCHEMBL28588178 | 0.86 | CHRM5 (0.70) | CHRM5CHKAMAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3149221-A | — | — | None | — | — | JP | disclosed |
| EP-3064486-B1 | PHENYL(META)ACRYLATE PRODUCTION METHOD AND PHENYL(META)ACRYLATE COMPOSITION | MITSUBISHI CHEM CORP (JP) | 2021-06-09 | — | — | EP | disclosed |
| CN-106715415-A | 3-amino-1, 5,6, 7-tetrahydro-4H-indol-4-ones | 拜耳制药股份公司 | 2017-05-24 | — | — | CN | disclosed |
| JP-H03149221-A | PRODUCTION OF POLYCARBONATE | DAICEL CHEM IND LTD | 1991-06-25 | — | — | JP | disclosed |
| US-5025083-A | Process for preparation of polycarbonate | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1991-06-18 | — | — | US | disclosed |
| EP-0382250-A2 | Process for preparation of polycarbonate | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |