Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18894300 | 0.79 | APP (0.56) | APPMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9763675 | 0.77 | HRH3 (0.41) | MAPTHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL22964321 | 0.77 | GRM5 (0.37) | APPHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL10465458 | 0.76 | HRH3 (0.43) | MAPTHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL1310397 | 0.76 | MAPT (0.54) | APPMAPTHTR2CHTR2BALDH1A1 | |
| SCHEMBL9763303 | 0.76 | NPC1 (0.46) | APPALDH1A1KDM4EKCNH2NPC1 | |
| SCHEMBL1310116 | 0.74 | APP (0.50) | APPMAPTALDH1A1KDM4ECYP1A2 | |
| SCHEMBL15131843 | 0.72 | APP (0.54) | APPMAPTHTR2AHTR2CALDH1A1 | |
| SCHEMBL31087902 | 0.72 | APP (0.54) | APPMAPTHTR2AHTR2CALDH1A1 | |
| SCHEMBL9763307 | 0.70 | MAOB (0.46) | APPALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990505-A | Treating asthma, bronchitis; adrenergic stimulants | GLAXO GROUP LIMITED (GB) | 1991-02-05 | — | — | US | disclosed |