Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 12/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8784770 | 0.87 | TACR1 (0.55) | TACR1MAPK8LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL16144912 | 0.83 | LMNA (0.53) | LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8785395 | 0.82 | MAPK8 (0.66) | TACR1MAPK8LMNABRD4 | |
| SCHEMBL1381652 | 0.79 | TSHR (0.55) | TACR1MAPK8LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8948131 | 0.78 | TACR1 (0.55) | TACR1MAPK8LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL1376897 | 0.76 | KMT2A (0.51) | TACR1LMNAKMT2ASMN1; SMN2DPP4 | |
| SCHEMBL9176574 | 0.76 | DPP4 (0.63) | TACR1MAPK8DPP4 | |
| SCHEMBL9763435 | 0.76 | TACR1 (0.43) | TACR1MAPK8LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL9763438 | 0.76 | TACR1 (0.43) | TACR1MAPK8LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL6109847 | 0.76 | DPP4 (0.56) | TACR1MAPK8DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004747-A | Isoquinolinones | MAY & BAKER LIMITED (GB) | 1991-04-02 | — | — | US | disclosed |
| EP-0326386-A2 | Isoquinolinones | MAY & BAKER LIMITED (GB) | 1989-08-02 | — | — | EP | disclosed |