Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 18/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 14/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 13/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | FPR3 | P25089 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | GPR183 | P32249 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764442 | 0.89 | ADRB2 (0.53) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL9764505 | 0.89 | SLC2A1 (0.50) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL10417908 | 0.88 | SLC2A1 (0.55) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL9764380 | 0.88 | ADRB2 (0.53) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL9764404 | 0.88 | SLC2A1 (0.53) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL9764439 | 0.88 | SLC2A1 (0.49) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL9764501 | 0.88 | SLC2A1 (0.55) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL9764346 | 0.88 | SLC2A1 (0.53) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| SCHEMBL9764767 | 0.87 | SLC2A1 (0.48) | ADRB2ADRB1ADRB3SLC6A2HTR2A | |
| Hydrochloric Acid SCHEMBL9021318 | 0.87 | ADRB2 (0.61) | ADRB2ADRB1ADRB3SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-B1 | DICHLOROANILINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-05-09 | — | — | EP | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |