Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.67 |
| ▸ | HTR1B | P28222 | 13/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | THPO | P40225 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | HTR1F | P30939 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | NOS1 | P29475 | 1/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269557 | 0.93 | HTR1D (0.61) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7488515 | 0.89 | HTR1D (0.72) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7485069 | 0.89 | CYP1A2 (0.68) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9369504 | 0.89 | HTR1D (0.59) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL7474065 | 0.86 | HTR1D (0.69) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7482687 | 0.84 | NOS1 (0.62) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7485584 | 0.84 | CYP1A2 (0.62) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7482190 | 0.83 | CYP1A2 (0.61) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7475958 | 0.83 | HTR1D (0.72) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4781939 | 0.83 | HTR1D (0.64) | HTR1DHTR1BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066660-A | INDOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-11-19 | — | — | US | disclosed |
| EP-0303506-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |