Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1824156 | 0.93 | RIPK1 (0.48) | RIPK1TAAR1TRPA1AOC3 | |
| SCHEMBL2838540 | 0.85 | RIPK1 (0.52) | RIPK1TAAR1TRPA1AOC3 | |
| SCHEMBL752037 | 0.85 | RIPK1 (0.52) | RIPK1TAAR1TRPA1AOC3 | |
| SCHEMBL27593435 | 0.83 | HRH1 (0.50) | SIGMAR1 | |
| SCHEMBL17183771 | 0.82 | RIPK1 (0.46) | RIPK1TAAR1TRPA1AOC3TSHR | |
| SCHEMBL17183799 | 0.82 | RIPK1 (0.46) | RIPK1TAAR1TRPA1AOC3TSHR | |
| SCHEMBL17183737 | 0.82 | RIPK1 (0.46) | RIPK1TAAR1TRPA1AOC3TSHR | |
| SCHEMBL17183640 | 0.82 | RIPK1 (0.46) | RIPK1TAAR1TRPA1AOC3TSHR | |
| SCHEMBL17183818 | 0.82 | RIPK1 (0.46) | RIPK1TAAR1TRPA1AOC3TSHR | |
| SCHEMBL17183735 | 0.82 | RIPK1 (0.46) | RIPK1TAAR1TRPA1AOC3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5041694-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1991-08-20 | — | — | US | disclosed |
| US-4965373-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1990-10-23 | — | — | US | disclosed |
| US-4895973-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & COMPANY (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0194610-B1 | SUBSTITUTED GLUTARIC ACID LACTONES IN THE TREATMENT OF HYPERLIPIDEMIA | G.D. Searle & Co. (US) | 1989-02-22 | — | — | EP | disclosed |
| US-4622338-A | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G. D. SEARLE & CO. (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0194610-A1 | Substituted glutaric acid lactones in the treatment of hyperlipidemia | G.D. Searle & Co. (US) | 1986-09-17 | — | — | EP | disclosed |