Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 17/20 | 0.70 |
| ▸ | DRD2 | P14416 | 10/20 | 0.70 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | DRD5 | P21918 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | THPO | P40225 | 2/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.63 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.63 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.63 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.63 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.63 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.63 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.63 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724467 | 0.82 | DRD1 (1.00) | DRD1DRD2TAAR1KDM4EDRD5 | |
| Bromide SCHEMBL11708014 | 0.81 | DRD1 (0.97) | DRD1DRD2TAAR1KDM4EDRD5 | |
| SCHEMBL2566292 | 0.81 | TAAR1 (0.97) | DRD1DRD2TAAR1KDM4EDRD5 | |
| SCHEMBL11168975 | 0.79 | DRD1 (0.80) | DRD1DRD2TAAR1KDM4EDRD5 | |
| SCHEMBL7629630 | 0.79 | HTR2C (0.66) | DRD1DRD2TAAR1KDM4EDRD5 | |
| SCHEMBL10746431 | 0.79 | DRD1 (0.80) | DRD1DRD2TAAR1KDM4EDRD5 | |
| Hydrochloric Acid SCHEMBL10345386 | 0.78 | DRD1 (0.66) | DRD1DRD2TAAR1KDM4EDRD5 | |
| Hydrochloric Acid SCHEMBL11160151 | 0.78 | DRD1 (0.80) | DRD1DRD2TAAR1KDM4EDRD5 | |
| Hydrochloric Acid SCHEMBL11155219 | 0.78 | DRD1 (0.80) | DRD1DRD2TAAR1KDM4EDRD5 | |
| Hydrochloric Acid SCHEMBL8518754 | 0.78 | DRD1 (0.80) | DRD1DRD2TAAR1KDM4EDRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996202-A | 1,2,4,5 tetrahydro benzazepine-3 compounds and antipsychotic use thereof | SCHERING CORPORATION (US) | 1991-02-26 | — | — | US | disclosed |
| US-4996202-A | 1,2,4,5 tetrahydro benzazepine-3 compounds and antipsychotic use thereof | SCHERING CORPORATION (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0153400-A1 | BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORPORATION (US) | 1985-09-04 | — | — | EP | disclosed |
| EP-0153400-A1 | BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORPORATION (US) | 1985-09-04 | — | — | EP | disclosed |
| EP-0135767-A1 | Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions | SCHERING CORPORATION (US) | 1985-04-03 | — | — | EP | disclosed |
| EP-0135767-A1 | Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions | SCHERING CORPORATION (US) | 1985-04-03 | — | — | EP | disclosed |
| WO-1985000808-A1 | BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORP. (US) | 1985-02-28 | — | — | WO | disclosed |
| WO-1985000808-A1 | BENZAZEPINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORP. (US) | 1985-02-28 | — | — | WO | disclosed |