Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764885 | 0.79 | ALOX5 (0.49) | PTPN1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9764925 | 0.75 | ALOX5 (0.45) | MAOBMAPTPSMB5 | |
| SCHEMBL9764854 | 0.73 | MAOB (0.40) | MAOBPTPN1MAPTKDM5AKDM7A | |
| SCHEMBL9764899 | 0.72 | MAOB (0.42) | MAOBMAPTPSMB5HPGD | |
| SCHEMBL10487743 | 0.72 | MAOB (0.49) | MAOBMAPTPSMB5CYP3A4MTNR1A | |
| SCHEMBL9764845 | 0.70 | MAOB (0.42) | MAOBMAPTPSMB5HPGD | |
| SCHEMBL9764924 | 0.69 | ALOX5 (0.43) | MAOBPSMB5 | |
| SCHEMBL10561811 | 0.68 | ALOX5 (0.43) | MAOBPSMB5 | |
| SCHEMBL669128 | 0.67 | NQO1 (0.43) | MAOB | |
| SCHEMBL10593685 | 0.66 | MAOB (0.41) | MAOBPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |