Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | HBB | P68871 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30148028 | 0.86 | KMT2A (0.61) | KMT2AALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL20181195 | 0.86 | KMT2A (0.61) | KMT2AALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL30523185 | 0.86 | KMT2A (0.61) | KMT2AALDH1A1L3MBTL1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL19717434 | 0.85 | KMT2A (0.60) | KMT2AALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL14315376 | 0.84 | NPY5R (0.64) | KMT2AALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL4849333 | 0.83 | KDM4E (0.67) | KMT2AALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL13958870 | 0.82 | KMT2A (0.67) | KMT2AALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL10163400 | 0.82 | KDM4E (0.66) | KMT2AALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL12158838 | 0.82 | KDM4E (0.66) | KMT2AALDH1A1L3MBTL1KDM4ELMNA | |
| SCHEMBL30523163 | 0.81 | KMT2A (0.64) | KMT2AALDH1A1L3MBTL1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0346939-A1 | Tricyclic lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |