Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 17/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.50 |
| ▸ | LOX | P28300 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10559925 | 0.99 | ALOX5 (0.57) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10559910 | 0.80 | ALOX5 (0.59) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10559599 | 0.80 | ALOX5 (0.59) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10611208 | 0.79 | ALOX5 (0.57) | ALOX5CYP1A2PTGESLMNALTA4H | |
| Potassium SCHEMBL10559851 | 0.79 | ALOX5 (0.57) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10563409 | 0.77 | ALOX5 (0.61) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL10560688 | 0.75 | ALOX5 (0.49) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL6334514 | 0.75 | ALOX5 (0.75) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL5689869 | 0.72 | ALOX5 (1.00) | ALOX5CYP1A2PTGESLMNALTA4H | |
| SCHEMBL9764848 | 0.72 | ALOX5 (0.49) | ALOX5CYP1A2PTGESLMNALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |