Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2683089 | 0.88 | MAPK1 (0.48) | CRBNMAPK1TLR4SMN1; SMN2NOS3 | |
| SCHEMBL1073565 | 0.86 | — | — | |
| SCHEMBL418184 | 0.81 | — | — | |
| SCHEMBL106510 | 0.81 | — | — | |
| SCHEMBL1523123 | 0.81 | — | — | |
| SCHEMBL16128180 | 0.81 | DRD2 (0.32) | CRBNMAPK1TLR4NOS3NOS1 | |
| SCHEMBL10934052 | 0.80 | — | — | |
| SCHEMBL339946 | 0.80 | — | — | |
| SCHEMBL10934045 | 0.80 | — | — | |
| SCHEMBL3664749 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0403487-A4 | NOVEL HMG-COA REDUCTASE INHIBITORS | — | 1991-06-05 | — | — | EP | disclosed |
| US-4996234-A | Anticholesterol agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0403487-A1 | NOVEL HMG-CoA REDUCTASE INHIBITORS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-12-27 | — | — | EP | disclosed |
| US-4900754-A | ANTICHOLESTEROL AGENTS | RORER PHARMACEUTICAL CORP. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4863957-A | ANTICHOLESTEROL AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| WO-1989005639-A1 | NOVEL HMG-CoA REDUCTASE INHIBITORS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-06-29 | — | — | WO | disclosed |