Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 11/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764930 | 0.87 | ALOX5 (0.51) | ALOX5LMNA | |
| SCHEMBL10559855 | 0.86 | ALOX5 (0.52) | ALOX5 | |
| SCHEMBL9764877 | 0.74 | ALOX5 (0.56) | ALOX5 | |
| SCHEMBL2391967 | 0.73 | ALOX5 (0.51) | ALOX5LMNA | |
| SCHEMBL10559599 | 0.73 | ALOX5 (0.59) | ALOX5LMNA | |
| SCHEMBL10563819 | 0.73 | ALOX5 (0.55) | ALOX5 | |
| SCHEMBL29787117 | 0.72 | POLB (1.00) | POLBLMNA | |
| SCHEMBL153365 | 0.72 | POLB (1.00) | POLBLMNA | |
| SCHEMBL29771433 | 0.72 | POLB (1.00) | POLBLMNA | |
| SCHEMBL9764967 | 0.72 | POLB (0.51) | POLBALOX5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422079-A4 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0422079-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012636-A1 | TRICYCLIC LIPOXYGENASE INHIBITING COMPOUNDS, COMPOSITIONS, METHODS OF USE | ABBOTT LABORATORIES (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0346939-A1 | Tricyclic lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4822811-A | Carbazole lipoxygenase inhibiting compounds, compositions and use | ABBOTT LABORATORIES (US) | 1989-04-18 | — | — | US | disclosed |