Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213217 | 0.87 | EPHX2 (0.53) | DPP4LMNAMEN1KMT2AEPHX2 | |
| SCHEMBL433785 | 0.81 | EPHX2 (0.53) | DPP4LMNAMEN1KMT2AEPHX2 | |
| SCHEMBL4866308 | 0.78 | DPP4 (0.58) | DPP4LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8485828 | 0.78 | DPP4 (0.53) | DPP4LMNAMEN1KMT2AEPHX2 | |
| SCHEMBL17761202 | 0.77 | DPP4 (0.56) | DPP4LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL436643 | 0.77 | DPP4 (0.52) | DPP4LMNAMEN1KMT2AEPHX2 | |
| SCHEMBL15795307 | 0.77 | SLC6A4 (0.54) | DPP4LMNAMEN1KMT2AEPHX2 | |
| SCHEMBL2439795 | 0.76 | LMNA (0.44) | DPP4LMNAMEN1KMT2AEPHX2 | |
| SCHEMBL10590819 | 0.76 | SLC6A4 (0.57) | DPP4SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL18440285 | 0.75 | EPHX2 (0.52) | DPP4LMNAMEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994465-A | Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0384320-A1 | Antihyperlipidemic and anti-atherosclerotic trisubstituted urea compounds | WARNER-LAMBERT COMPANY (US) | 1990-08-29 | — | — | EP | disclosed |