Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKLR | P30613 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799890 | 1.00 | POLB (0.43) | POLBNAALAD2FOLH1LMNATDP1 | |
| SCHEMBL9799897 | 0.93 | POLB (0.38) | POLBLMNATDP1KLKB1PRSS1 | |
| SCHEMBL9765587 | 0.88 | POLB (0.40) | POLBNAALAD2FOLH1LMNATDP1 | |
| SCHEMBL9765550 | 0.88 | POLB (0.40) | POLBNAALAD2FOLH1LMNATDP1 | |
| SCHEMBL195323 | 0.88 | POLB (0.40) | POLBNAALAD2FOLH1LMNATDP1 | |
| SCHEMBL9765574 | 0.88 | POLB (0.40) | POLBNAALAD2FOLH1LMNATDP1 | |
| SCHEMBL9765570 | 0.88 | POLB (0.40) | POLBNAALAD2FOLH1LMNATDP1 | |
| SCHEMBL9765547 | 0.88 | POLB (0.40) | POLBNAALAD2FOLH1LMNATDP1 | |
| SCHEMBL9765588 | 0.85 | POLB (0.38) | POLBNAALAD2FOLH1LMNATDP1 | |
| SCHEMBL9765594 | 0.85 | POLB (0.38) | POLBNAALAD2FOLH1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023268-A | Therapy for cerebral edema | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-06-11 | — | — | US | disclosed |
| EP-0231619-B1 | 3-PHENOXY(OR PHENYLTHIO)CYCLOPENTANECARBONYLAMINO ACID ANALOGUES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-03-06 | — | — | EP | disclosed |
| US-4888351-A | TREATMENT OF CEREBRAL EDEMA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-12-19 | — | — | US | disclosed |
| US-4829078-A | CEREBRAL EDEMA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-05-09 | — | — | US | disclosed |
| US-4783476-A | 3-Phenoxy (or phenylthio)-cyclopentanecarbonylamino acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-11-08 | — | — | US | disclosed |
| EP-0231619-A2 | 3-Phenoxy(or phenylthio)cyclopentanecarbonylamino acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1987-08-12 | — | — | EP | disclosed |