Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 5/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9765586 | 1.00 | KMT2A (0.39) | KMT2AMRGPRX4POLBCA2CA1 | |
| SCHEMBL9765587 | 0.93 | POLB (0.40) | POLBPLGPYGLLMNATDP1 | |
| SCHEMBL9765547 | 0.93 | POLB (0.40) | POLBPLGPYGLLMNATDP1 | |
| SCHEMBL195323 | 0.93 | POLB (0.40) | POLBPLGPYGLLMNATDP1 | |
| SCHEMBL9765574 | 0.93 | POLB (0.40) | POLBPLGPYGLLMNATDP1 | |
| SCHEMBL9765550 | 0.93 | POLB (0.40) | POLBPLGPYGLLMNATDP1 | |
| SCHEMBL9765570 | 0.93 | POLB (0.40) | POLBPLGPYGLLMNATDP1 | |
| SCHEMBL9765606 | 0.91 | ITGB2 (0.36) | MRGPRX4CA2CA1PLGPYGL | |
| SCHEMBL9765542 | 0.91 | ITGB2 (0.36) | MRGPRX4CA2CA1PLGPYGL | |
| SCHEMBL9799899 | 0.89 | PYGL (0.36) | KMT2AMRGPRX4POLBPYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231619-B1 | 3-PHENOXY(OR PHENYLTHIO)CYCLOPENTANECARBONYLAMINO ACID ANALOGUES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-03-06 | — | — | EP | claimed |
| US-5023268-A | Therapy for cerebral edema | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-06-11 | — | — | US | disclosed |
| US-4888351-A | TREATMENT OF CEREBRAL EDEMA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-12-19 | — | — | US | disclosed |
| US-4829078-A | CEREBRAL EDEMA | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-05-09 | — | — | US | disclosed |
| US-4783476-A | 3-Phenoxy (or phenylthio)-cyclopentanecarbonylamino acid analogues | ONO PHARMACEUTICAL CO., LTD. (JP) | 1988-11-08 | — | — | US | disclosed |