Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 3/20 | 0.66 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.66 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.66 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431826 | 0.95 | CACNA1C (0.71) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL11869125 | 0.91 | CACNA1C (0.66) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7380278 | 0.90 | — | — | |
| SCHEMBL7375672 | 0.89 | CACNA1F (0.54) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7379516 | 0.89 | CACNA1C (0.54) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL9672747 | 0.89 | CACNA1C (0.58) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10743484 | 0.88 | CACNA1C (0.64) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL11781966 | 0.88 | CACNA1C (0.67) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL10481007 | 0.88 | CACNA1C (0.64) | CACNA1CCACNA1FCACNA1DCACNA1S | |
| Hydrochloric Acid SCHEMBL7374125 | 0.88 | CACNA1F (0.53) | CACNA1CCACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4285955-A | CARDIOTONIC, HYPOTENSIVE, AND ANTISPASMOTIC AGENTS; VASODILATION | BAYER AKTIENGESELLSCHAFT (DE) | 1981-08-25 | — | — | US | claimed |
| US-4988717-A | Optically active 1,4-dihydropyridine esters useful for treating circulatory illnesses | BAYER AKTIENGESELLSCHAFT (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4931525-A | Optical active (meth)acrylamides and polymers thereof for racemate resolution | BAYER AKTIENGESELLSCHAFT (DE) | 1990-06-05 | — | — | US | disclosed |
| US-4849433-A | The compound, (⃡)1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarboxylic acid, methyl isobutyl ester, compositions containing same and a method for effecting coronary dilation | BAYER AKTIENGESELLSCHAFT (DE) | 1989-07-18 | — | — | US | disclosed |
| US-4798840-A | Coronary-active fluorine-containing 1,4-dihydropyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1989-01-17 | — | — | US | disclosed |
| US-4510310-A | 1,4-Dihydro-2,6-dimethyl-4-(2'-chlorophenyl)-3,5-dicarboxylic acid,methyl or ethyl,trifluoroethyl ester | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-09 | — | — | US | disclosed |