Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7374125 | 0.99 | CACNA1F (0.53) | CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7374069 | 0.95 | CACNA1F (0.60) | CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7379621 | 0.89 | CACNA1C (0.59) | CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9765702 | 0.89 | CACNA1C (0.66) | CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7381384 | 0.85 | ADORA3 (0.46) | CACNA1C | |
| SCHEMBL7431826 | 0.84 | CACNA1C (0.71) | CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7380278 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL7380766 | 0.84 | ADORA3 (0.46) | CACNA1C | |
| SCHEMBL7379516 | 0.83 | CACNA1C (0.54) | CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7273146 | 0.83 | CACNA1C (0.62) | CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4393070-A | HYPOTENSIVE, VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-07-12 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4307103-A | TREATMENT OF HYPERTENSION AND CARDIOVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-12-22 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |