Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 8/20 | 0.84 |
| ▸ | LMNA | P02545 | 5/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.84 |
| ▸ | MAPT | P10636 | 4/20 | 0.84 |
| ▸ | TSHR | P16473 | 3/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.84 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.84 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.84 |
| ▸ | NPC1 | O15118 | 1/20 | 0.84 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.84 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.84 |
| ▸ | PGR | P06401 | 1/20 | 0.84 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.84 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.84 |
| ▸ | HTR1A | P08908 | 1/20 | 0.84 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11402267 | 0.99 | LMNA (0.85) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11849741 | 0.95 | CACNA1C (0.77) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 | |
| Nicardipine SCHEMBL7625913 | 0.95 | CYP1A2 (0.87) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11845797 | 0.94 | CACNA1C (0.75) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL10554411 | 0.94 | LMNA (0.93) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL11835050 | 0.94 | LMNA (0.75) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9765743 | 0.92 | CACNA1C (0.89) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11844936 | 0.92 | CACNA1C (0.89) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8215921 | 0.92 | CACNA1C (0.89) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10587969 | 0.92 | CACNA1C (0.77) | CACNA1CLMNACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3985758-A | 1,4-Dihydropyridine derivatives | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) | 1976-10-12 | — | — | US | claimed |
| US-4988717-A | Optically active 1,4-dihydropyridine esters useful for treating circulatory illnesses | BAYER AKTIENGESELLSCHAFT (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4849433-A | The compound, (⃡)1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarboxylic acid, methyl isobutyl ester, compositions containing same and a method for effecting coronary dilation | BAYER AKTIENGESELLSCHAFT (DE) | 1989-07-18 | — | — | US | disclosed |
| US-4510310-A | 1,4-Dihydro-2,6-dimethyl-4-(2'-chlorophenyl)-3,5-dicarboxylic acid,methyl or ethyl,trifluoroethyl ester | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-09 | — | — | US | disclosed |
| US-3985758-A | 1,4-Dihydropyridine derivatives | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JA) | 1976-10-12 | — | — | US | disclosed |