Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 6/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054519 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2GLAMAPTTSHRPDE4A | |
| SCHEMBL1546096 | 0.79 | MAPT (0.49) | SMN1; SMN2GLAMAPTTSHRPDE4A | |
| SCHEMBL8355057 | 0.77 | SMN1; SMN2 (0.36) | SMN1; SMN2GLAMAPTTSHRPDE4A | |
| SCHEMBL4467734 | 0.77 | TSHR (0.43) | SMN1; SMN2GLAMAPTTSHRPDE4A | |
| SCHEMBL10864511 | 0.76 | TSHR (0.39) | TSHRPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL10864253 | 0.76 | KMT2A (0.39) | SMN1; SMN2GLAMAPTTSHRPDE4A | |
| SCHEMBL3297433 | 0.75 | KMT2A (0.54) | SMN1; SMN2GLAMAPTTSHRPDE4A | |
| SCHEMBL9414222 | 0.75 | TSHR (0.52) | SMN1; SMN2MAPTTSHRPDE4AADORA2A | |
| SCHEMBL4656127 | 0.74 | MAPT (0.42) | MAPTTSHRHSD17B10KDM4EMEN1 | |
| SCHEMBL14819960 | 0.72 | TSHR (0.40) | SMN1; SMN2GLAMAPTTSHRPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383868-A4 | 1,3-UNSYMMETRICAL STRAIGHT CHAIN ALKYL-SUBSTITUTED 8-PHENYLXANTHINES | — | 1991-12-04 | — | — | EP | disclosed |
| EP-0383868-A1 | 1,3-UNSYMMETRICAL STRAIGHT CHAIN ALKYL-SUBSTITUTED 8-PHENYLXANTHINES | MARION LABORATORIES, INC. (US) | 1990-08-29 | — | — | EP | disclosed |
| WO-1990000056-A1 | 1,3-UNSYMMETRICAL STRAIGHT CHAIN ALKYL-SUBSTITUTED 8-PHENYLXANTHINES | MARION LABORATORIES, INC. (US) | 1990-01-11 | — | — | WO | disclosed |