Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 11/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9400880 | 0.79 | HTT (0.55) | HTTPTPN11MAPTMEN1KMT2A | |
| SCHEMBL25274946 | 0.74 | GPR119 (0.55) | HTTPTPN11MAPTMEN1KMT2A | |
| SCHEMBL30166221 | 0.74 | GPR119 (0.55) | HTTPTPN11MAPTMEN1KMT2A | |
| SCHEMBL10996666 | 0.74 | PTPN11 (0.57) | HTTPTPN11MAPTMEN1KMT2A | |
| SCHEMBL9482270 | 0.74 | MAPT (0.51) | HTTPTPN11MAPTMEN1KMT2A | |
| SCHEMBL9400997 | 0.74 | MAPT (0.55) | HTTPTPN11MAPTMEN1KMT2A | |
| SCHEMBL9400930 | 0.74 | SMN1; SMN2 (0.71) | HTTPTPN11MAPTMEN1KMT2A | |
| SCHEMBL24053853 | 0.73 | GPR119 (0.59) | PTPN11MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL9766029 | 0.73 | PIK3CD (0.37) | MAPTKMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10849115 | 0.72 | GAA (0.56) | HTTMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4994460-A | Treatment or prevention of disorders resulting from central nervous system anoxia | BRISTOL-MYERS SQUIBB CO. (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0400661-A1 | Agents for treatment of brain ischemia | Bristol-Myers Squibb Company (US) | 1990-12-05 | — | — | EP | disclosed |
| US-4423049-A | TRANQUILIZERS | MEAD JOHNSON & COMPANY (US) | 1983-12-27 | — | — | US | disclosed |