Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.49 |
| ▸ | CDC25A | P30304 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | EBP | Q15125 | 2/20 | 0.43 |
| ▸ | CDC25B | P30305 | 2/20 | 0.42 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 2/20 | 0.41 |
| ▸ | ACACA | Q13085 | 2/20 | 0.41 |
| ▸ | FNTA | P49354 | 2/20 | 0.41 |
| ▸ | FNTB | P49356 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766747 | 1.00 | HMGCR (0.49) | HMGCRCDC25ACYP2C19HIF1AEBP | |
| SCHEMBL28831684 | 0.85 | HMGCR (0.54) | HMGCRCDC25AEBPCDC25BNPC1L1 | |
| SCHEMBL9766739 | 0.83 | GPBAR1 (0.53) | CDC25ACYP2C19HIF1AMEN1USP2 | |
| SCHEMBL9766744 | 0.83 | GPBAR1 (0.53) | CDC25ACYP2C19HIF1AMEN1USP2 | |
| SCHEMBL9766820 | 0.81 | HMGCR (0.46) | HMGCRCDC25ACYP2C19HIF1AEBP | |
| SCHEMBL9766722 | 0.81 | HMGCR (0.46) | HMGCRCDC25ACYP2C19HIF1AEBP | |
| SCHEMBL6687443 | 0.75 | CYP2D6 (0.59) | CDC25ACYP2C19CDC25BNPC1L1MEN1 | |
| SCHEMBL27568855 | 0.75 | CYP2D6 (0.59) | CDC25ACYP2C19CDC25BNPC1L1MEN1 | |
| SCHEMBL14116734 | 0.74 | CDC25A (0.54) | CDC25AEBPCDC25BNPC1L1MEN1 | |
| SCHEMBL14034589 | 0.74 | CDC25A (0.54) | CDC25AEBPCDC25BNPC1L1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023250-A | Anticholesterol agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |