Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.73 |
| ▸ | PTGES | O14684 | 2/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | ACACA | Q13085 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 7/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.42 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | CRYAB | P02511 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766763 | 1.00 | HMGCR (0.73) | HMGCRPTGESACLYACACAHSD11B1 | |
| SCHEMBL9766794 | 0.88 | HMGCR (0.71) | HMGCRPTGESACLYACACAHSD11B1 | |
| SCHEMBL9766787 | 0.88 | HMGCR (0.71) | HMGCRPTGESACLYACACAHSD11B1 | |
| SCHEMBL9644252 | 0.86 | HMGCR (0.71) | HMGCRPTGESACLYACACAHSD11B1 | |
| SCHEMBL13384620 | 0.85 | HMGCR (0.79) | HMGCRPTGESACLYACACAHSD11B1 | |
| SCHEMBL9766734 | 0.84 | USP2 (0.59) | HMGCREBP | |
| SCHEMBL9766813 | 0.84 | HMGCR (0.53) | HMGCRPTGESACLYACACAPRKAG1 | |
| SCHEMBL9766817 | 0.84 | HMGCR (0.53) | HMGCRPTGESACLYACACAPRKAG1 | |
| SCHEMBL9766765 | 0.83 | HMGCR (0.74) | HMGCRPTGESACLYACACAHSD11B1 | |
| SCHEMBL9766761 | 0.83 | HMGCR (0.74) | HMGCRPTGESACLYACACAHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023250-A | Anticholesterol agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |