Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TYMP | P19971 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BAD | Q92934 | 1/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202541 | 0.78 | SERPINE1 (0.42) | MAPTTYMPMAPK14BCL2L1BAD | |
| SCHEMBL8901808 | 0.78 | TYMP (0.48) | MAPTTYMPMAPK14BCL2L1BAD | |
| SCHEMBL13290009 | 0.76 | SERPINE1 (0.41) | MAPTTYMPMAPK14BCL2L1BAD | |
| SCHEMBL18812265 | 0.75 | NPC1 (0.41) | MAPTNPC1RAB9A | |
| SCHEMBL10300262 | 0.73 | BCL2L1 (0.55) | MAPTBCL2L1BADNOTUMNPC1 | |
| SCHEMBL197346 | 0.73 | BCL2L1 (0.55) | MAPTBCL2L1BADNOTUMNPC1 | |
| SCHEMBL10337645 | 0.73 | BCL2L1 (0.55) | MAPTBCL2L1BADNOTUMNPC1 | |
| SCHEMBL12562793 | 0.73 | BCL2L1 (0.55) | MAPTBCL2L1BADNOTUMNPC1 | |
| SCHEMBL19165324 | 0.73 | TYMP (0.41) | MAPTTYMPMAPK14PTGS2 | |
| SCHEMBL4159589 | 0.73 | NPC1 (0.40) | MAPTHTTTYMPMAPK14BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985464-A | Drug compositions for local treatment of alopecia areata | HAPPLE RUDOLF (DE) | 1991-01-15 | — | — | US | claimed |
| WO-2022188012-A1 | USE OF SILYLAMINO RARE EARTH COMPOUND IN CATALYSIS OF REACTION OF ISATIN COMPOUND AND CYCLOPROPENONE COMPOUND | 苏州大学 | 2022-09-15 | — | — | WO | disclosed |