Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRYAB | P02511 | 5/20 | 0.58 |
| ▸ | CRYAA | P02489 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 2/20 | 0.51 |
| ▸ | HMGCR | P04035 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766870 | 1.00 | CRYAB (0.58) | CRYABCRYAAUSP2ALDH1A1CYP3A4 | |
| SCHEMBL9766822 | 0.92 | CRYAB (0.57) | CRYABCRYAAUSP2ALDH1A1CYP3A4 | |
| SCHEMBL9766824 | 0.92 | CRYAB (0.57) | CRYABCRYAAUSP2ALDH1A1CYP3A4 | |
| SCHEMBL9766800 | 0.89 | CRYAB (0.54) | CRYABCRYAAUSP2ALDH1A1CYP3A4 | |
| SCHEMBL9766804 | 0.89 | CRYAB (0.54) | CRYABCRYAAUSP2ALDH1A1CYP3A4 | |
| SCHEMBL15123748 | 0.89 | CRYAB (0.61) | CRYABCRYAAUSP2ALDH1A1CYP3A4 | |
| SCHEMBL13499193 | 0.89 | CRYAB (0.61) | CRYABCRYAAUSP2ALDH1A1CYP3A4 | |
| SCHEMBL3231652 | 0.89 | CRYAB (0.61) | CRYABCRYAAUSP2ALDH1A1CYP3A4 | |
| SCHEMBL26641675 | 0.89 | CRYAB (0.61) | CRYABCRYAAUSP2ALDH1A1CYP3A4 | |
| SCHEMBL9766812 | 0.88 | MAPT (0.49) | CRYABCRYAAUSP2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023250-A | Anticholesterol agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-06-11 | — | — | US | claimed |
| US-5023250-A | Anticholesterol agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |