Sugi Predict

Sugi Predict / Targets / CRYAB

CRYAB

Alpha-crystallin B chain · P02511 · CRYAB on Sugi Atlas →

8,289 patent compounds predicted against CRYAB, 7,525 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL288306 SCHEMBL288306 0.80 5/20
SCHEMBL288307 SCHEMBL288307 0.80 5/20
SCHEMBL568417 SCHEMBL568417 0.80 5/20
SCHEMBL620303 SCHEMBL620303 0.77 5/20
SCHEMBL990785 SCHEMBL990785 0.74 5/20
SCHEMBL990786 SCHEMBL990786 0.74 5/20
Euphorbol Euphorbol (SCHEMBL568715) 0.71 5/20
SCHEMBL1712616 SCHEMBL1712616 0.62 5/20
SCHEMBL568416 SCHEMBL568416 0.62 5/20
Clavarinone Clavarinone (SCHEMBL606233) 0.59 5/20
Clavarinone Clavarinone (SCHEMBL606234) 0.59 5/20
SCHEMBL288164 SCHEMBL288164 0.57 5/20
SCHEMBL568714 SCHEMBL568714 0.54 5/20
Obtusifoliol Obtusifoliol (SCHEMBL569375) 0.47 5/20
SCHEMBL2508949 SCHEMBL2508949 0.47 5/20
Obtusifoliol Obtusifoliol (SCHEMBL2511101) 0.47 5/20
SCHEMBL620304 SCHEMBL620304 0.80 4/20
SCHEMBL619869 SCHEMBL619869 0.79 4/20
SCHEMBL1278368 SCHEMBL1278368 0.64 4/20
SCHEMBL1153293 SCHEMBL1153293 0.51 4/20

Clinical trials — most relevant to CRYAB by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Management of Retinitis Pigmentosa Via Combination of Wharton's Jelly-derived Mesenchymal Stem Cells and Magnovision PHASE3COMPLETED
Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery PHASE3UNKNOWN
CB-PRP in Retinitis Pigmentosa and Dry Age-related Macular Degeneration PHASE3COMPLETED
Cell Therapy in Failure Syndromes in Limbal Stem Cells PHASE2COMPLETED
Scleral Buckling for Retinal Detachment Prevention in Genetically Confirmed Stickler Syndrome PHASE2WITHDRAWN
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors PHASE1COMPLETED
PBA Use for Treatment of ATF6-/- Patients EARLY_PHASE1SUSPENDED
Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts nanCOMPLETED
Studies of Families With Hereditary Cataracts nanCOMPLETED
Vitreous Proteomics of Patients Suffering From Pseudoexfoliation Syndrome nanACTIVE_NOT_RECRUITING
Proteomic Study of Tears From Patients With a PAX6 Mutation nanCOMPLETED
PMCF Retrospective Study Outcomes of a Monofocal Toric Intraocular Lens nanCOMPLETED
Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts nanCOMPLETED
Genetic Diagnosis in Congenital Cataracts nanCOMPLETED
MRB 0.3% Serum Effectiveness on 2 Early Clinical Markers of Photoinduced Cutaneous Aging: Actinic Lentigo and Actinic Keratosis nanUNKNOWN
The Molecular Pathogenesis Study of Cataract nanUNKNOWN
Heart Aging When Near Vision Difficulty Begins nanCOMPLETED
Gyrate Atrophy of the Choroid and Retina nanCOMPLETED
Shanghai High Myopia Study nanRECRUITING
Acute Passive Heating in Healthy Older Adults nanCOMPLETED
Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F nanACTIVE_NOT_RECRUITING
Characterization of Retinal Vascular Disease in Eyes With Mild to Moderate NPDR in Diabetes Type 2 nanCOMPLETED
Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy (PRK) nanCOMPLETED
Genetic Study of Age-Related Macular Degeneration nanCOMPLETED
The Role of SNP of ECM and MMP on the Development of Pathological High Myopia nanUNKNOWN
Proteomic Biomarker Identification in Age-Related Macular Degeneration, Diabetic Retinopathy and Retinal Detachment nanRECRUITING
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a CRYAB binder may also engage these)

ProteinNameSimilarity
Q5ENY9 — 1.000 Q5ENY9 →
Q60HG8 — 1.000 Q60HG8 →
P23927 — 1.000 P23927 →
Q7M2W6 — 1.000 Q7M2W6 →
Q5R9K0 — 1.000 Q5R9K0 →
P23928 — 1.000 P23928 →
P05811 — 1.000 P05811 →
P41316 — 1.000 P41316 →
P02510 — 1.000 P02510 →
Q9EPF3 — 1.000 Q9EPF3 →
P02498 — 0.995 P02498 →
P02506 — 0.994 P02506 →
P02504 — 0.993 P02504 →
Q91311 — 0.991 Q91311 →
Q05557 — 0.991 Q05557 →
P68285 — 0.990 P68285 →
P02485 — 0.989 P02485 →
P82531 — 0.989 P82531 →
P68286 — 0.989 P68286 →
P02505 — 0.989 P02505 →
P02487 — 0.989 P02487 →
P02502 — 0.989 P02502 →
P02488 — 0.988 P02488 →
P02482 — 0.988 P02482 →
P02480 — 0.988 P02480 →
P02478 — 0.988 P02478 →
P02494 — 0.988 P02494 →
P02470 — 0.988 P02470 →
P02484 — 0.987 P02484 →
P02475 — 0.987 P02475 →