Phthalic Acid

Phthalic Acid

SCHEMBL9768559

NCC(=O)O.O=C(O)c1ccccc1C(=O)O

nearest known ligand 0.70

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Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D

The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.70
ALOX15 P16050 1/20 0.70
AKR1C3 P42330 1/20 0.54
KDM4E B2RXH2 2/20 0.52
HMGB1 P09429 2/20 0.52
HPGD P15428 2/20 0.52
CA12 O43570 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA4 P22748 1/20 0.52
CA6 P23280 1/20 0.52
CA7 P43166 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
CA9 Q16790 1/20 0.52
NAPRT Q6XQN6 1/20 0.52
CA14 Q9ULX7 1/20 0.52
GLRA1 P23415 1/20 0.50
SLC6A9 P48067 1/20 0.50
OR51E2 Q9H255 1/20 0.50
MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phthalic Acid SCHEMBL30578745 1.00 ALDH1A1 (0.70) ALDH1A1ALOX15AKR1C3KDM4EHMGB1
Phthalic Acid SCHEMBL28210326 0.98 ALDH1A1 (0.67) ALDH1A1ALOX15AKR1C3KDM4EHMGB1
Phthalic Acid SCHEMBL28694900 0.98 ALDH1A1 (0.67) ALDH1A1ALOX15AKR1C3KDM4EHMGB1
Phthalic Acid SCHEMBL28966847 0.87 ALDH1A1 (0.74) ALDH1A1ALOX15AKR1C3KDM4EHMGB1
Phthalic Acid SCHEMBL29039922 0.87 ALDH1A1 (0.74) ALDH1A1ALOX15AKR1C3KDM4EHMGB1
Phthalic Acid SCHEMBL8162329 0.87 ALDH1A1 (0.74) ALDH1A1ALOX15AKR1C3KDM4EHMGB1
Phthalic Acid SCHEMBL30999729 0.87 ALDH1A1 (0.74) ALDH1A1ALOX15AKR1C3KDM4EHMGB1
Phthalic Acid SCHEMBL30122831 0.87 ALDH1A1 (0.74) ALDH1A1ALOX15AKR1C3KDM4EHMGB1
Salicylic Acid SCHEMBL4212394 0.87 ALDH1A1 (0.75) ALDH1A1ALOX15KDM4EHMGB1HPGD
SCHEMBL7820247 0.86 ALDH1A1 (0.64) ALDH1A1ALOX15AKR1C3KDM4EHMGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4994297-A Method of using fast pyrolysis liquids as liquid smoke ENSYN ENGINEERING ASSOCIATES, INC. (CA) 1991-02-19 US disclosed
US-4876108-A HEATING GROUND WOOD WITHOUT OXYGEN, COOLING, EXTRACTING WITH WATER ENSYN ENGINEERING ASSOCIATES INC. (CA) 1989-10-24 US disclosed
US-4207377-A PHOTOREPRODUCTIVE COATING COMPOSITION AND COPY PAPER THE SHERWIN-WILLIAMS COMPANY (US) 1980-06-10 US disclosed