⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9254617 | 0.83 | LMNA (0.41) | — | |
| SCHEMBL17938546 | 0.80 | — | — | |
| SCHEMBL179519 | 0.75 | — | — | |
| SCHEMBL4533971 | 0.73 | — | — | |
| SCHEMBL312391 | 0.71 | — | — | |
| SCHEMBL11719036 | 0.71 | — | — | |
| SCHEMBL31295849 | 0.71 | LMNA (0.33) | — | |
| SCHEMBL23660496 | 0.70 | LMNA (0.30) | — | |
| SCHEMBL981922 | 0.69 | — | — | |
| SCHEMBL23660487 | 0.67 | LMNA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073892-B2 | Indazolyl triazol derivatives | MERCK SERONO S.A. (CH) | 2015-07-07 | — | — | US | disclosed |
| US-9073892-B2 | Indazolyl triazol derivatives | MERCK SERONO S.A. (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) | 2013-10-17 | — | — | US | disclosed |
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) | 2013-10-17 | — | — | US | disclosed |
| US-7511063-B2 | High affinity quinoline-based kinase ligands | SCHERING CORPORATION (US) | 2009-03-31 | — | — | US | disclosed |
| US-20080045568-A1 | Novel high affinity quinoline-based kinase ligands | SCHERING CORPORATION | 2008-02-21 | — | — | US | disclosed |
| US-5030625-A | Applying to phytopathogen | SANDOZ LTD. (CH) | 1991-07-09 | — | — | US | disclosed |
| EP-0191269-B1 | NOVEL HOMOPROPARGYLAMINES | SANDOZ AG (CH) | 1991-03-06 | — | — | EP | disclosed |
| US-4684661-A | Anti-fungal homopropargylamines, compositions, and method of use therefor | SANDOZ LTD. (CH) | 1987-08-04 | — | — | US | disclosed |
| EP-0191269-A2 | Novel homopropargylamines | SANDOZ AG (CH) | 1986-08-20 | — | — | EP | disclosed |
| US-4064257-A | Thiazole cardiovascular agents | SYNTEX (U.S.A.) INC. (US) | 1977-12-20 | — | — | US | disclosed |