Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 3/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768862 | 1.00 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| Hydrochloric Acid SCHEMBL9769045 | 0.98 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| Hydrochloric Acid SCHEMBL9769046 | 0.98 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL10655053 | 0.83 | SMN1; SMN2 (0.59) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| Isonicotinoylhydrazone Of Acetophenone SCHEMBL6637694 | 0.83 | GAA (0.76) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| Isonicotinoylhydrazone Of Acetophenone SCHEMBL6637701 | 0.83 | GAA (0.76) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL14938560 | 0.82 | MAPT (0.78) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL27177847 | 0.82 | SMN1; SMN2 (0.73) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL27177854 | 0.82 | SMN1; SMN2 (0.73) | NPC1RAB9ASMN1; SMN2GAAKDM4E | |
| SCHEMBL10650228 | 0.81 | SMN1; SMN2 (0.60) | NPC1RAB9ASMN1; SMN2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023334-A | Anthelmintic pyridinyl acylhydrazones | THE UPJOHN COMPANY (US) | 1991-06-11 | — | — | US | claimed |
| EP-0214158-A1 | ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS | THE UPJOHN COMPANY (US) | 1987-03-18 | — | — | EP | claimed |
| WO-1986004582-A1 | ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS | THE UPJOHN COMPANY (US) | 1986-08-14 | — | — | WO | claimed |
| US-5011932-A | Anthelmintic pyridinyl acylhydrazones derivatives | UPJOHN COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| EP-0214158-A1 | ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS | THE UPJOHN COMPANY (US) | 1987-03-18 | — | — | EP | disclosed |
| WO-1986004582-A1 | ANTHELMINTIC PYRIDINYL ACYLHYDRAZONES, METHOD OF USE AND COMPOSITIONS | THE UPJOHN COMPANY (US) | 1986-08-14 | — | — | WO | disclosed |