Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769832 | 0.80 | HMGCR (0.45) | HMGCRGAANPSR1LMNARAB9A | |
| SCHEMBL9769861 | 0.78 | HMGCR (0.45) | HMGCRGAAMAPTMEN1KMT2A | |
| SCHEMBL1507996 | 0.75 | KMT2A (0.54) | GAAMAPTMEN1KMT2ANPSR1 | |
| SCHEMBL9769868 | 0.72 | HMGCR (0.61) | HMGCRGAAMAPTMEN1KMT2A | |
| SCHEMBL9769862 | 0.72 | HMGCR (0.61) | HMGCRGAAMAPTMEN1KMT2A | |
| SCHEMBL9859450 | 0.70 | MAPT (0.53) | GAAMAPTMEN1KMT2ANPSR1 | |
| SCHEMBL9855514 | 0.70 | MAPT (0.53) | GAAMAPTMEN1KMT2ANPSR1 | |
| SCHEMBL9769786 | 0.70 | HMGCR (0.74) | HMGCR | |
| SCHEMBL9769845 | 0.70 | HMGCR (0.43) | HMGCRGAAMAPTNPSR1LMNA | |
| SCHEMBL10990974 | 0.70 | ALDH1A1 (0.43) | GAAMAPTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070206-A | INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; ANTICHOLESTEROL, ANTILIPEMIC | BRISTOL-MYERS COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-5010205-A | Antihypercholesterolemic tetrazol-1-yl intermediates | BRISTOL-MYERS COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0355820-A1 | Antihypercholesterolemic tetrazol-1-yl compounds | Bristol-Myers Squibb Company (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4870187-A | ANTILIPEMIC, ATHEROSCLEROSIS | BRISTOL-MYERS COMPANY (US) | 1989-09-26 | — | — | US | disclosed |