Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769899 | 1.00 | HMGCR (0.54) | HMGCRALDH1A1RAB9ANPC1KCNJ1 | |
| SCHEMBL9769859 | 0.86 | HMGCR (0.53) | HMGCRALDH1A1RAB9ANPC1KCNJ1 | |
| SCHEMBL10548599 | 0.74 | HMGCR (0.56) | HMGCRALDH1A1LMNAGAATSHR | |
| SCHEMBL9769863 | 0.74 | HMGCR (0.56) | HMGCRALDH1A1LMNAGAATSHR | |
| SCHEMBL9769881 | 0.73 | HMGCR (0.82) | HMGCR | |
| SCHEMBL9769814 | 0.73 | HMGCR (0.82) | HMGCR | |
| SCHEMBL9769896 | 0.73 | HMGCR (0.82) | HMGCR | |
| SCHEMBL9769801 | 0.73 | HMGCR (0.82) | HMGCR | |
| SCHEMBL9769832 | 0.71 | HMGCR (0.45) | HMGCRALDH1A1RAB9ANPC1KCNJ1 | |
| SCHEMBL10554642 | 0.71 | HMGCR (0.46) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070206-A | INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; ANTICHOLESTEROL, ANTILIPEMIC | BRISTOL-MYERS COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-5010205-A | Antihypercholesterolemic tetrazol-1-yl intermediates | BRISTOL-MYERS COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0355820-A1 | Antihypercholesterolemic tetrazol-1-yl compounds | Bristol-Myers Squibb Company (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4870187-A | ANTILIPEMIC, ATHEROSCLEROSIS | BRISTOL-MYERS COMPANY (US) | 1989-09-26 | — | — | US | disclosed |