Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769943 | 1.00 | HMGCR (0.64) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL9769851 | 0.89 | HMGCR (0.51) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL9769858 | 0.89 | HMGCR (0.51) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL9769870 | 0.89 | HMGCR (0.68) | HMGCRHPGD | |
| SCHEMBL9769865 | 0.89 | HMGCR (0.68) | HMGCRHPGD | |
| SCHEMBL9769926 | 0.87 | HMGCR (0.77) | HMGCR | |
| SCHEMBL9769923 | 0.87 | HMGCR (0.77) | HMGCR | |
| SCHEMBL9769868 | 0.84 | HMGCR (0.61) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL9769862 | 0.84 | HMGCR (0.61) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL9726639 | 0.83 | HMGCR (0.64) | HMGCRKDM4EHPGDHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070206-A | INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; ANTICHOLESTEROL, ANTILIPEMIC | BRISTOL-MYERS COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-5010205-A | Antihypercholesterolemic tetrazol-1-yl intermediates | BRISTOL-MYERS COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0355820-A1 | Antihypercholesterolemic tetrazol-1-yl compounds | Bristol-Myers Squibb Company (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4870187-A | ANTILIPEMIC, ATHEROSCLEROSIS | BRISTOL-MYERS COMPANY (US) | 1989-09-26 | — | — | US | disclosed |