Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9769858 | 1.00 | HMGCR (0.51) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL10437581 | 0.90 | HMGCR (0.53) | HMGCRHPGDALDH1A1 | |
| SCHEMBL10437579 | 0.90 | HMGCR (0.53) | HMGCRHPGDALDH1A1 | |
| SCHEMBL9769943 | 0.89 | HMGCR (0.64) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL9769949 | 0.89 | HMGCR (0.64) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL9769922 | 0.88 | HMGCR (0.61) | HMGCR | |
| SCHEMBL9769919 | 0.88 | HMGCR (0.61) | HMGCR | |
| SCHEMBL9798888 | 0.82 | HMGCR (0.60) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL9798880 | 0.82 | HMGCR (0.60) | HMGCRKDM4EHPGDHTTHSD17B10 | |
| SCHEMBL9769868 | 0.80 | HMGCR (0.61) | HMGCRKDM4EHPGDHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070206-A | INHIBITORS OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE; ANTICHOLESTEROL, ANTILIPEMIC | BRISTOL-MYERS COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-5010205-A | Antihypercholesterolemic tetrazol-1-yl intermediates | BRISTOL-MYERS COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| EP-0355820-A1 | Antihypercholesterolemic tetrazol-1-yl compounds | Bristol-Myers Squibb Company (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4870187-A | ANTILIPEMIC, ATHEROSCLEROSIS | BRISTOL-MYERS COMPANY (US) | 1989-09-26 | — | — | US | disclosed |