Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770183 | 0.77 | DPP4 (0.37) | DPP4HDAC9GAAMMEALDH1A1 | |
| SCHEMBL6183360 | 0.76 | BRD4 (0.48) | NOTUMGAAALDH1A1L3MBTL1HTT | |
| SCHEMBL30645248 | 0.73 | NOTUM (0.45) | NOTUMHDAC9ALDH1A1KMT2APOLB | |
| SCHEMBL8078233 | 0.73 | NOTUM (0.45) | NOTUMHDAC9ALDH1A1KMT2APOLB | |
| SCHEMBL8114506 | 0.71 | NOTUM (0.43) | NOTUMHDAC9ALDH1A1POLBL3MBTL1 | |
| SCHEMBL13127862 | 0.71 | CXCR5 (0.43) | NOTUMHDAC9 | |
| SCHEMBL18584167 | 0.70 | — | — | |
| SCHEMBL18588374 | 0.70 | — | — | |
| SCHEMBL12571286 | 0.69 | NOTUM (0.42) | NOTUMHDAC9ALDH1A1KMT2APOLB | |
| SCHEMBL8243032 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247764-B1 | 4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES, AND INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION | ORION-YHTYMÀ OY (FI) | 1991-08-14 | — | — | EP | disclosed |
| US-5026868-A | Alpha-2 receptor antagonists | FARMOS-YHTYMA OY (FI) | 1991-06-25 | — | — | US | disclosed |
| US-4933359-A | 4(5)-substituted imidazole derivatives as α2 -adrenergic receptor blockers | FARMOS-YHTYMA OY (FI) | 1990-06-12 | — | — | US | disclosed |
| EP-0247764-A1 | 4(5)-Substituted imidazole derivatives, and intermediates and processes for their preparation | ORION-YHTYMÀ OY (FI) | 1987-12-02 | — | — | EP | disclosed |