Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 8/20 | 0.50 |
| ▸ | THRB | P10828 | 8/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9771025 | 0.99 | THRA (0.52) | THRATHRBCYP4A11CYP4F2DPP4 | |
| SCHEMBL9078703 | 0.85 | THRA (0.62) | THRATHRBHAO1 | |
| SCHEMBL9813799 | 0.84 | HPGD (0.49) | THRATHRBCYP4A11CYP4F2 | |
| SCHEMBL9074980 | 0.84 | THRA (0.65) | THRATHRBHAO1 | |
| SCHEMBL9231878 | 0.84 | DPP4 (0.64) | THRATHRBDPP4NPC1RAB9A | |
| SCHEMBL9075736 | 0.84 | THRA (0.65) | THRATHRBHAO1 | |
| SCHEMBL9078334 | 0.84 | THRA (0.65) | THRATHRBHAO1 | |
| SCHEMBL7826472 | 0.84 | PDE4B (0.57) | THRATHRBCYP4A11CYP4F2DPP4 | |
| SCHEMBL9813840 | 0.84 | THRA (0.60) | THRATHRBCYP4A11CYP4F2DPP4 | |
| SCHEMBL8898170 | 0.83 | DPP4 (0.62) | THRATHRBDPP4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5075447-A | Biochemical immobilization; immunoassay | HOFFMANN-LA ROCHE INC. (US) | 1991-12-24 | — | — | US | disclosed |
| EP-0178450-B1 | METAL COMPLEXES TO WHICH AN IMMUNOLOGICALLY ACTIVE MATERIAL CAN BE OR IS COUPLED, THEIR PREPARATION AND USE | F. HOFFMANN-LA ROCHE AG (CH) | 1991-04-17 | — | — | EP | disclosed |
| US-4745076-A | Ruthenium complexes useful as carriers for immunologically active materials | HOFFMANN-LA ROCHE INC. (US) | 1988-05-17 | — | — | US | disclosed |