SCHEMBL9772001

SCHEMBL9772001

CCn1c(=O)[nH]c(=O)c2c(-c3ccc(F)cc3)c(C=CC(O)CC(O)CC(=O)O)c(C(C)C)nc21

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 8/20 0.59
TBXA2R P21731 2/20 0.59
ADRA1A P35348 2/20 0.59
ESR1 P03372 1/20 0.59
CHRM1 P11229 1/20 0.59
PDE4A P27815 1/20 0.59
PDE4D Q08499 3/20 0.51
NR1I2 O75469 2/20 0.51
ALDH1A1 P00352 1/20 0.51
CYP3A4 P08684 1/20 0.51
PDE6D O43924 1/20 0.51
CYP2C9 P11712 3/20 0.46
SIRT6 Q8N6T7 2/20 0.46
NR4A2 P43354 2/20 0.46
ABCC3 O15438 1/20 0.46
ABCB11 O95342 1/20 0.46
PGR P06401 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
RXRA P19793 1/20 0.46
CCKAR P32238 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9771998 1.00 HMGCR (0.59) HMGCRTBXA2RADRA1AESR1CHRM1
SCHEMBL9735621 0.92 HMGCR (0.53) HMGCRTBXA2RADRA1AESR1CHRM1
SCHEMBL9771983 0.92 HMGCR (0.56) HMGCRTBXA2RADRA1AESR1CHRM1
SCHEMBL9771984 0.92 HMGCR (0.56) HMGCRTBXA2RADRA1AESR1CHRM1
SCHEMBL9772118 0.91 HMGCR (0.60) HMGCRTBXA2RADRA1AESR1CHRM1
SCHEMBL9772121 0.91 HMGCR (0.60) HMGCRTBXA2RADRA1AESR1CHRM1
SCHEMBL9772067 0.85 HMGCR (0.50) HMGCRTBXA2RADRA1AESR1CHRM1
SCHEMBL9735593 0.82 HMGCR (0.54) HMGCRTBXA2RADRA1AESR1CHRM1
SCHEMBL9734698 0.82 HMGCR (0.43) HMGCRTBXA2RADRA1AESR1CHRM1
SCHEMBL9734676 0.82 HMGCR (0.43) HMGCRTBXA2RADRA1AESR1CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5075311-A Anticholesterol agents BAYER AKTIENGESELLSCHAFT (DE) 1991-12-24 US claimed