Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PDE6D | O43924 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734676 | 1.00 | HMGCR (0.43) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9381546 | 0.93 | ESR1 (0.42) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9772067 | 0.86 | HMGCR (0.50) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9736896 | 0.82 | KDM4E (0.45) | PDE4AKDM4EALDH1A1HTTCYP3A4 | |
| SCHEMBL9388048 | 0.82 | KDM4E (0.45) | PDE4AKDM4EALDH1A1HTTCYP3A4 | |
| SCHEMBL9772001 | 0.82 | HMGCR (0.59) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9771998 | 0.82 | HMGCR (0.59) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9383396 | 0.82 | KDM4E (0.48) | PDE4AKDM4EALDH1A1HTTCYP3A4 | |
| SCHEMBL9735142 | 0.81 | HMGCR (0.49) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9735125 | 0.81 | HMGCR (0.49) | HMGCRESR1CHRM1TBXA2RPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145959-A | Enzyme inhibitors; antilipemic agents; treatment of atherosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | disclosed |
| US-5075311-A | Anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1991-12-24 | — | — | US | disclosed |