Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.52 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | DGKA | P23743 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27296401 | 1.00 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2LMNAASAH1 | |
| SCHEMBL9773153 | 1.00 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2LMNAASAH1 | |
| SCHEMBL27229985 | 0.86 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2LMNAASAH1 | |
| SCHEMBL28139414 | 0.86 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2LMNAASAH1 | |
| SCHEMBL28871864 | 0.84 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2LMNAASAH1 | |
| SCHEMBL5668366 | 0.84 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2LMNAASAH1 | |
| SCHEMBL8754509 | 0.83 | MAPK1 (0.52) | SMN1; SMN2LMNATSHRPOLBTP53 | |
| SCHEMBL2512047 | 0.82 | CYP3A4 (0.49) | SMN1; SMN2LMNAALDH1A1PPARGCYP3A4 | |
| SCHEMBL19347208 | 0.81 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2LMNATSHR | |
| SCHEMBL19792371 | 0.81 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2LMNACERT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5043346-A | Amino acid esters, pharmaceuticals containing them, and the use thereof in learning disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-27 | — | — | US | disclosed |