SCHEMBL9775227

SCHEMBL9775227

CC(C)Oc1ccc(CSc2cnn(C(C)(C)C)c(=O)c2Cl)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.70
MEN1 O00255 2/20 0.70
KMT2A Q03164 2/20 0.70
NPC1 O15118 1/20 0.70
GALR3 O60755 1/20 0.70
NR2F2 P24468 1/20 0.70
GPR183 P32249 1/20 0.70
GPR35 Q9HC97 1/20 0.70
GAA P10253 3/20 0.48
MAPT P10636 2/20 0.48
PKM P14618 1/20 0.48
SMN1; SMN2 Q16637 6/20 0.42
NPSR1 Q6W5P4 2/20 0.42
LMNA P02545 4/20 0.42
CYP1A2 P05177 2/20 0.40
CYP2C19 P33261 2/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
HPGD P15428 2/20 0.38
HTT P42858 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9775136 0.90 MEN1 (0.69) RAB9AMEN1KMT2ANPC1GALR3
SCHEMBL9827883 0.89 RAB9A (0.64) RAB9AMEN1KMT2ANPC1GALR3
SCHEMBL10704572 0.88 MEN1 (0.62) RAB9AMEN1KMT2ANPC1GALR3
SCHEMBL9828510 0.87 MEN1 (0.61) RAB9AMEN1KMT2ANPC1GALR3
SCHEMBL9829510 0.86 MEN1 (0.63) RAB9AMEN1KMT2ANPC1GALR3
SCHEMBL9157542 0.86 MEN1 (0.60) RAB9AMEN1KMT2ANPC1GALR3
SCHEMBL9775230 0.85 MEN1 (0.71) RAB9AMEN1KMT2ANPC1GALR3
SCHEMBL9775168 0.85 MEN1 (0.74) RAB9AMEN1KMT2ANPC1GALR3
SCHEMBL9775193 0.85 NPC1 (0.81) RAB9AMEN1KMT2ANPC1GALR3
SCHEMBL9830508 0.83 MEN1 (0.69) RAB9AMEN1KMT2ANPC1GALR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5026850-A Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, fungicidal compositions NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1991-06-25 US disclosed
US-4877787-A Benzylthio pyridazinone derivatives, preparation thereof, and insecticidal acaricidal, fungicidal compositions NISSAN CHEMICAL INDUSTRIES (JP) 1989-10-31 US disclosed
EP-0134439-B1 PYRIDAZINONE DERIVATIVES, PREPARATION THEREOF AND INSECTICIDAL, ACARICIDAL, FUNGICIDAL COMPOSITIONS NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1988-08-24 EP disclosed
EP-0134439-A1 Pyridazinone derivatives, preparation thereof and insecticidal, acaricidal, fungicidal compositions NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1985-03-20 EP disclosed