Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.78 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31061131 | 0.88 | HRH3 (1.00) | HRH3CHRNA7HRH4KDM4EHSD17B10 | |
| SCHEMBL3990045 | 0.87 | HRH3 (0.63) | HRH3CHRNA7SIGMAR1HRH4 | |
| SCHEMBL10508496 | 0.87 | HRH3 (0.97) | HRH3CHRNA7SIGMAR1HRH4KDM4E | |
| SCHEMBL9026162 | 0.84 | HRH3 (0.63) | HRH3CHRNA7SIGMAR1HRH4KDM4E | |
| SCHEMBL9027129 | 0.83 | HRH3 (0.66) | HRH3CHRNA7SIGMAR1HRH4KDM4E | |
| SCHEMBL9223267 | 0.83 | HRH3 (0.66) | HRH3CHRNA7HRH4KDM4EHSD17B10 | |
| SCHEMBL8332622 | 0.83 | HRH3 (0.65) | HRH3CHRNA7SIGMAR1HRH4 | |
| SCHEMBL9027094 | 0.82 | HRH3 (0.64) | HRH3CHRNA7HRH4KDM4EHSD17B10 | |
| SCHEMBL9026157 | 0.82 | HRH3 (0.64) | HRH3CHRNA7HRH4KDM4EHSD17B10 | |
| SCHEMBL8688791 | 0.82 | CHRNA7 (0.84) | HRH3CHRNA7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023254-A | Administering antiestrogens | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-06-11 | — | — | US | disclosed |
| US-4943572-A | 1-carbamoylalkyl-2-phenylindoles, pharmaceutical compositions and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |