Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.76 |
| ▸ | MET | P08581 | 13/20 | 0.64 |
| ▸ | JAK2 | O60674 | 4/20 | 0.64 |
| ▸ | INSR | P06213 | 3/20 | 0.64 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.64 |
| ▸ | PLK4 | O00444 | 2/20 | 0.64 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.64 |
| ▸ | ABL1 | P00519 | 2/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.64 |
| ▸ | FES | P07332 | 2/20 | 0.64 |
| ▸ | CSF1R | P07333 | 2/20 | 0.64 |
| ▸ | LYN | P07948 | 2/20 | 0.64 |
| ▸ | RET | P07949 | 2/20 | 0.64 |
| ▸ | IGF1R | P08069 | 2/20 | 0.64 |
| ▸ | ROS1 | P08922 | 2/20 | 0.64 |
| ▸ | SRC | P12931 | 2/20 | 0.64 |
| ▸ | FER | P16591 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15932993 | 0.86 | ALK (1.00) | ALKMETJAK2INSRMAP4K3 | |
| SCHEMBL17310246 | 0.86 | ALK (1.00) | ALKMETJAK2INSRMAP4K3 | |
| SCHEMBL5254859 | 0.84 | ALK (0.78) | ALKMETJAK2INSRMAP4K3 | |
| SCHEMBL5930845 | 0.80 | ALK (0.72) | ALKMETJAK2INSRMAP4K3 | |
| SCHEMBL5255269 | 0.80 | ALK (0.71) | ALKMETJAK2INSRMAP4K3 | |
| SCHEMBL5930528 | 0.79 | ALK (0.70) | ALKMETJAK2INSRMAP4K3 | |
| SCHEMBL30454647 | 0.79 | MET (0.77) | ALKMETJAK2 | |
| SCHEMBL488371 | 0.79 | MET (0.77) | ALKMETJAK2 | |
| SCHEMBL5256255 | 0.78 | ALK (0.69) | ALKMETJAK2INSRMAP4K3 | |
| Crizotinib SCHEMBL93829 | 0.78 | MET (1.00) | ALKMETJAK2INSRMAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280729-A2 | CD20 THERAPIES, CD22 THERAPIES, AND COMBINATION THERAPIES WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) - EXPRESSING CELL | Novartis AG (CH) | 2018-02-14 | — | — | EP | disclosed |
| WO-2016164731-A2 | CD20 THERAPIES, CD22 THERAPIES, AND COMBINATION THERAPIES WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) - EXPRESSING CELL | NOVARTIS AG (CH) | 2016-10-13 | — | — | WO | disclosed |
| WO-2016126608-A1 | CAR-EXPRESSING CELLS AGAINST MULTIPLE TUMOR ANTIGENS AND USES THEREOF | NOVARTIS AG (CH) | 2016-08-11 | — | — | WO | disclosed |
| EP-2426213-A1 | Marker for sunitnib resistance formation | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2012-03-07 | — | — | EP | disclosed |