Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 4/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22860166 | 0.84 | HRH4 (0.51) | HRH4CDC7JAK2HTR3AMAPK1 | |
| SCHEMBL9778491 | 0.84 | HTR2A (0.47) | HRH4CNR1HTR3ACNR2 | |
| SCHEMBL4289522 | 0.82 | HTT (0.55) | HRH4CDC7JAK2MAPK1 | |
| SCHEMBL4785792 | 0.82 | JAK2 (0.54) | HRH4CDC7CNR1JAK2CNR2 | |
| SCHEMBL9778567 | 0.82 | ALDH1A1 (0.56) | HRH4CDC7JAK2HTR3AMAPK1 | |
| SCHEMBL17982403 | 0.82 | MAPK1 (0.54) | CDC7CNR1JAK2CNR2MAPK1 | |
| SCHEMBL9778391 | 0.82 | CNR1 (0.46) | HRH4CDC7CNR1CNR2MAPK1 | |
| Hydrochloric Acid SCHEMBL9778506 | 0.81 | HTT (0.53) | HRH4CDC7JAK2MAPK1 | |
| SCHEMBL9778418 | 0.80 | LRRK2 (0.61) | HRH4CDC7JAK2 | |
| SCHEMBL14208177 | 0.79 | ALDH1A1 (0.48) | HRH4CDC7CNR1JAK2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5077405-A | Condensation of corresponding phenylsulfonyl compound with condensation agent, cyanation, reduction | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0417653-A1 | 3-(1-Substituted-4-piperazinyl)-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4954503-A | ANALGESIC, ANTIPSYCHOTIC AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-09-04 | — | — | US | disclosed |