Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 3/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 4/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9779010 | 0.83 | ALDH1A1 (0.54) | ALDH1A1IMPDH2KDM4EERN1CYP2A6 | |
| SCHEMBL5440842 | 0.74 | KDM4E (0.43) | ALDH1A1IMPDH2KDM4EERN1TDP1 | |
| SCHEMBL14156855 | 0.72 | ALDH1A1 (0.59) | ALDH1A1IMPDH2KDM4ETDP1PIM1 | |
| SCHEMBL1093997 | 0.69 | ALDH1A1 (0.56) | ALDH1A1IMPDH2KDM4ECYP2A6CYP1A2 | |
| SCHEMBL29392367 | 0.69 | ALDH1A1 (0.50) | ALDH1A1KDM4EERN1CYP2A6CYP1A2 | |
| SCHEMBL39718 | 0.69 | ALDH1A1 (0.50) | ALDH1A1KDM4EERN1CYP2A6CYP1A2 | |
| SCHEMBL347177 | 0.68 | ERN1 (0.43) | ALDH1A1KDM4EERN1CYP2A6CYP1A2 | |
| Methyl Alcohol SCHEMBL27597852 | 0.68 | ALDH1A1 (0.46) | ALDH1A1KDM4EERN1CYP2A6CYP1A2 | |
| SCHEMBL838056 | 0.68 | ALDH1A1 (0.54) | ALDH1A1IMPDH2KDM4ECYP2A6CYP1A2 | |
| SCHEMBL1093392 | 0.68 | ALDH1A1 (0.54) | ALDH1A1IMPDH2KDM4EERN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999369-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0246077-B1 | HETEROPOLYCYCLIC AROMATIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-11-22 | — | — | EP | disclosed |
| US-4910218-A | With a hydroxy containing secondary amine group | BURROUGHS WELLCOME CO. (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0246077-A1 | Heteropolycyclic aromatic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1987-11-19 | — | — | EP | disclosed |