Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Biphenyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | ACR | P10323 | 1/20 | 0.51 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL28161687 | 0.94 | PARP10 (0.63) | MAPTTDP1PARP10KMT2AL3MBTL1 | |
| Benzoic Acid SCHEMBL28346471 | 0.94 | PARP10 (0.63) | MAPTTDP1PARP10KMT2AL3MBTL1 | |
| SCHEMBL3144029 | 0.92 | HSD17B10 (0.59) | MAPTTDP1PARP10KMT2AL3MBTL1 | |
| SCHEMBL9189715 | 0.91 | HSD17B10 (0.62) | MAPTTDP1PARP10KMT2AL3MBTL1 | |
| SCHEMBL9696360 | 0.91 | PARP10 (0.66) | MAPTTDP1PARP10KMT2AL3MBTL1 | |
| SCHEMBL23202513 | 0.91 | PARP10 (0.66) | MAPTTDP1PARP10KMT2AL3MBTL1 | |
| SCHEMBL817796 | 0.90 | PARP10 (0.63) | MAPTTDP1PARP10KMT2AL3MBTL1 | |
| Terephthalic Acid SCHEMBL28437942 | 0.90 | PARP10 (0.63) | MAPTTDP1PARP10KMT2AL3MBTL1 | |
| SCHEMBL2462824 | 0.88 | PARP10 (0.61) | MAPTTDP1PARP10KMT2AL3MBTL1 | |
| SCHEMBL622771 | 0.88 | PARP10 (0.72) | MAPTTDP1PARP10KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4981607-A | Liquid-crystalline organopolysiloxanes and methods for their preparation | TORAY SILICONE COMPANY LIMITED (JP) | 1991-01-01 | — | — | US | disclosed |