Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | F10 | P00742 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9781429 | 0.92 | PDE3B (0.68) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL9781454 | 0.87 | PDE3B (0.64) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL10922000 | 0.85 | PDE3B (0.56) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL10771071 | 0.83 | PDE3B (0.54) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL8264680 | 0.83 | PDE3B (0.64) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL10463602 | 0.82 | PDE3B (0.57) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL10925412 | 0.82 | PDE3B (0.60) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL10769306 | 0.82 | PDE3B (0.60) | GPR119PDE3BPDE3AABCB11MAOA | |
| Hydrochloric Acid SCHEMBL7322526 | 0.82 | PDE3B (0.63) | GPR119PDE3BPDE3AABCB11MAOA | |
| SCHEMBL10770212 | 0.82 | PDE3B (0.57) | GPR119PDE3BPDE3AABCB11MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0193013-B1 | BENZIMIDAZOLYL-PYRIDAZINONES | MERCK PATENT GmbH (DE) | 1989-04-19 | — | — | EP | claimed |
| US-5026705-A | Benzimidazolylpyridazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-06-25 | — | — | US | disclosed |
| US-4923869-A | INOTROPIC, VASODILATING, AND ANTITHROMBOTIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-05-08 | — | — | US | disclosed |
| EP-0193013-B1 | BENZIMIDAZOLYL-PYRIDAZINONES | MERCK PATENT GmbH (DE) | 1989-04-19 | — | — | EP | disclosed |
| EP-0193013-A2 | Benzimidazolyl-pyridazinones | MERCK PATENT GmbH (DE) | 1986-09-03 | — | — | EP | disclosed |