Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAOA | P21397 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9620895 | 0.74 | CYP3A4 (0.46) | CYP3A4MAPTKDM4EMAOAALDH1A1 | |
| SCHEMBL5855343 | 0.74 | MAPT (0.50) | CYP3A4MAPTKDM4EMAOAALDH1A1 | |
| SCHEMBL19365876 | 0.73 | CTNNB1 (0.45) | CYP3A4MAPTKDM4EMAOAALDH1A1 | |
| SCHEMBL9781956 | 0.70 | CYP3A4 (0.42) | CYP3A4MAPTKDM4EMAOAALDH1A1 | |
| SCHEMBL14023255 | 0.69 | CYP3A4 (0.41) | CYP3A4MAPTMAOAALDH1A1LMNA | |
| SCHEMBL9782064 | 0.69 | PLK1 (0.34) | CYP3A4MAPTKDM4EMAOAALDH1A1 | |
| Hydrochloric Acid SCHEMBL4789436 | 0.68 | CYP3A4 (0.39) | CYP3A4MAPTMAOAALDH1A1 | |
| SCHEMBL15982610 | 0.67 | EP300 (0.46) | CYP3A4MAPTKDM4ELMNAHPGD | |
| SCHEMBL15982615 | 0.67 | EP300 (0.46) | CYP3A4MAPTKDM4ELMNAHPGD | |
| SCHEMBL15982322 | 0.67 | EP300 (0.46) | CYP3A4MAPTKDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997836-A | Inhibitor of platelet activating factor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-03-05 | — | — | US | disclosed |
| US-4937246-A | ABSORBED EASILY FROM INTESTINES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-06-26 | — | — | US | disclosed |
| EP-0368670-A1 | Trisubstituted piperazine compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-05-16 | — | — | EP | disclosed |
| EP-0318235-A2 | PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof | Takeda Chemical Industries, Ltd. (JP) | 1989-05-31 | — | — | EP | disclosed |