SCHEMBL9620895

SCHEMBL9620895

COc1cc2c(cc1OC)CCC[C]C2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.46
MAPT P10636 2/20 0.46
KDM4E B2RXH2 4/20 0.43
MAOA P21397 4/20 0.43
CHRNA7 P36544 2/20 0.43
MAOB P27338 2/20 0.43
SLC6A4 P31645 1/20 0.43
DRD1 P21728 2/20 0.41
DRD4 P21917 2/20 0.41
DRD5 P21918 2/20 0.41
DRD2 P14416 1/20 0.41
DRD3 P35462 1/20 0.41
GAA P10253 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
PDE4D Q08499 1/20 0.39
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38
HTR2B P41595 1/20 0.38
CA7 P43166 1/20 0.38
ALDH1A1 P00352 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5855343 0.88 MAPT (0.50) CYP3A4MAPTKDM4EMAOACHRNA7
SCHEMBL59900 0.80 MAPT (0.62) CYP3A4MAPTKDM4EMAOACHRNA7
SCHEMBL5045112 0.80 MAPT (0.62) CYP3A4MAPTKDM4EMAOACHRNA7
SCHEMBL14481557 0.75 MAPT (0.68) CYP3A4MAPTKDM4EMAOACHRNA7
SCHEMBL29924708 0.75 MAPT (0.68) CYP3A4MAPTKDM4EMAOACHRNA7
SCHEMBL2594537 0.75 MAPT (0.68) CYP3A4MAPTKDM4EMAOACHRNA7
SCHEMBL577943 0.74 CYP3A4 (0.45) CYP3A4MAPTKDM4EMAOACHRNA7
SCHEMBL9781963 0.74 CYP3A4 (0.41) CYP3A4MAPTKDM4EMAOACHRNA7
SCHEMBL9620937 0.72 KDM4E (0.45) CYP3A4MAPTKDM4EMAOACHRNA7
SCHEMBL17487029 0.71 MAPT (0.50) CYP3A4MAPTKDM4EMAOACHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0284359-B1 1,4-DISUBSTITUTED PIPERAZINE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1992-01-08 EP disclosed
US-4997836-A Inhibitor of platelet activating factor TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1991-03-05 US disclosed
EP-0369810-A2 PAF antagonists as anti-hyperendothelinemia agents Takeda Chemical Industries, Ltd. (JP) 1990-05-23 EP disclosed
EP-0368670-A1 Trisubstituted piperazine compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1990-05-16 EP disclosed
US-4880809-A HYPOTENSIVE AGENTS, AMIDE DERIVATIVES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-11-14 US disclosed
EP-0284359-A1 1,4-Disubstituted piperazine compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1988-09-28 EP disclosed