SCHEMBL9782263

SCHEMBL9782263

O=S1(=O)CC[C]=Cc2ccccc21

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.31
PLCG1 P19174 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL255968 0.69 GPR3 (0.46) GPR3PLCG1
SCHEMBL3536271 0.68 GPR3 (0.33) GPR3PLCG1
SCHEMBL3966527 0.68 GPR3 (0.33) GPR3PLCG1
SCHEMBL10517257 0.67 GPR3 (0.32) GPR3PLCG1
SCHEMBL1196801 0.66 GPR3 (0.39) GPR3
SCHEMBL30365485 0.65 MEN1 (0.32) GPR3PLCG1
SCHEMBL30708217 0.61 CXCR2 (0.35) GPR3PLCG1
SCHEMBL19194985 0.61 CXCR2 (0.35) GPR3PLCG1
SCHEMBL6756663 0.61 MAPK1 (0.35)
SCHEMBL3714644 0.60 CA12 (0.35) GPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4997836-A Inhibitor of platelet activating factor TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1991-03-05 US disclosed
US-4937246-A ABSORBED EASILY FROM INTESTINES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-06-26 US disclosed
EP-0369810-A2 PAF antagonists as anti-hyperendothelinemia agents Takeda Chemical Industries, Ltd. (JP) 1990-05-23 EP disclosed
EP-0368670-A1 Trisubstituted piperazine compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1990-05-16 EP disclosed