Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 14/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11061309 | 1.00 | ELANE (0.52) | ELANEGPBAR1SLC6A2SLC6A3KMT2A | |
| SCHEMBL9782863 | 0.92 | ELANE (0.55) | ELANEGPBAR1SLC6A2SLC6A3KMT2A | |
| SCHEMBL11486285 | 0.88 | ELANE (0.47) | ELANEGPBAR1 | |
| SCHEMBL11062621 | 0.88 | ELANE (0.43) | ELANEGPBAR1SLC6A2SLC6A3KMT2A | |
| SCHEMBL11061674 | 0.84 | ELANE (0.43) | ELANEGPBAR1SLC6A2SLC6A3KMT2A | |
| SCHEMBL11063454 | 0.83 | ELANE (0.45) | ELANESLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL9698851 | 0.81 | ELANE (0.34) | ELANESLC6A2TDP1 | |
| SCHEMBL11063535 | 0.80 | FOLH1 (0.43) | ELANESLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL11276416 | 0.80 | ELANE (0.55) | ELANEGPBAR1 | |
| SCHEMBL11061653 | 0.80 | ELANE (0.42) | ELANESLC6A2SLC6A3KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5055573-A | Reacting substituted azetidinone with glyoxalate ester, halogenating, reacting with phosphine, oxidizing, cyclizing, deprotecting | MERCK & CO., INC. (US) | 1991-10-08 | — | — | US | disclosed |
| US-4775669-A | ANTIBIOTIC | MERCK & CO., INC. (US) | 1988-10-04 | — | — | US | disclosed |
| US-4543257-A | PENICILLIN ANTIBIOTICS | MERCK & CO., INC. (US) | 1985-09-24 | — | — | US | disclosed |
| US-4348320-A | PENICILLIN INTERMEDIATES | MERCK & CO., INC. (US) | 1982-09-07 | — | — | US | disclosed |