Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 9/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11063454 | 0.83 | ELANE (0.45) | ELANESLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL9782863 | 0.81 | ELANE (0.55) | ELANESLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL11063535 | 0.80 | FOLH1 (0.43) | ELANESLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL11061309 | 0.80 | ELANE (0.52) | ELANESLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL9782425 | 0.80 | ELANE (0.52) | ELANESLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL11061674 | 0.78 | ELANE (0.43) | ELANESLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL9680869 | 0.77 | CES2 (0.36) | CES2 | |
| SCHEMBL11062039 | 0.77 | ELANE (0.41) | ELANESLC6A2SLC6A3KMT2ATDP1 | |
| SCHEMBL11486285 | 0.77 | ELANE (0.47) | ELANEALDH1A1 | |
| SCHEMBL11062621 | 0.76 | ELANE (0.43) | ELANESLC6A2SLC6A3KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002564-B1 | DERIVATIVES OF 7-OXO-1-AZABICYCLO(3.2.0)-HEPT-2-ENE-2-CARBOXYLIC ACID, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES | BEECHAM GROUP PLC (GB) | 1984-06-20 | — | — | EP | disclosed |
| US-4431587-A | AMINO ACID DERIVATIVE ANTIVBIOTICS | BEECHAM GROUP LIMITED (GB) | 1984-02-14 | — | — | US | disclosed |
| US-4405637-A | CARBAPENICILLIN | BEECHAM GROUP LIMITED (GB) | 1983-09-20 | — | — | US | disclosed |
| US-4401595-A | 4-Allyl azetidinone intermediate for β-lactam antibacterial agents | BEECHAM GROUP LIMITED (GB) | 1983-08-30 | — | — | US | disclosed |
| US-4350703-A | β-Lactam antibacterial agents | BEECHAM GROUP LIMITED (GB) | 1982-09-21 | — | — | US | disclosed |
| US-4347181-A | Intermediates for producing bicyclic β-lactam-antibiotics | BEECHAM GROUP LIMITED (GB) | 1982-08-31 | — | — | US | disclosed |
| US-4289696-A | BETA-LACTAMASE INHIBITORY AGENTS WHICH ENHANCE ACTIVITY OF A PENICICILLIN OR CEPHALOSPORIN | BEECHAM GROUP LIMITED (GB) | 1981-09-15 | — | — | US | disclosed |
| US-4223038-A | THIENAMYCINS | BEECHAM GROUP LIMITED (GB) | 1980-09-16 | — | — | US | disclosed |
| EP-0002564-A1 | Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates | BEECHAM GROUP PLC (GB) | 1979-06-27 | — | — | EP | disclosed |