Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 2/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19999186 | 0.80 | CYP17A1 (0.67) | CYP17A1CYP11B1CYP11B2CYP19A1KMT2A | |
| SCHEMBL9194274 | 0.77 | CYP17A1 (0.67) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9267609 | 0.77 | CYP17A1 (0.67) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9192367 | 0.77 | CYP17A1 (0.67) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9194562 | 0.77 | CYP17A1 (0.67) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9266596 | 0.77 | CYP17A1 (0.67) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| Hydrochloric Acid SCHEMBL9316769 | 0.76 | CYP17A1 (0.65) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9196681 | 0.75 | CYP17A1 (0.64) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL9192918 | 0.73 | CYP19A1 (0.61) | CYP17A1CYP11B1CYP11B2CYP19A1 | |
| SCHEMBL2351262 | 0.72 | CYP11B2 (0.57) | CYP17A1CYP11B1CYP11B2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0340153-A1 | N-substituted imidazoles, process for their preparation and their use in medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-11-02 | — | — | EP | claimed |
| US-5045558-A | Aromatase inhibitors, prevention of estrogen biosynthesis, treatment of breast cancer | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | disclosed |
| EP-0340153-A1 | N-substituted imidazoles, process for their preparation and their use in medicaments | SCHERING AKTIENGESELLSCHAFT (DE) | 1989-11-02 | — | — | EP | disclosed |